A diet rich in antioxidants may reduce the risk of H. pylori infection

People who eat a well-balanced diet that contains enough antioxidants from fruits and vegetables may have a lower risk. Heliobacter pylori infection, according to a new report.

In particular, patients with H pylori Infections were more likely to score lower on the Dietary Antioxidant Index (DAI), which was established to look at the antioxidant profile of the entire diet.

Available evidence suggests that diet has an important role in development H pylori infection. Therefore, protective nutritional factors are important from a public health point of view,” Farzad Shadvar, professor of nutrition at the Iranian University of Medical Sciences and a member of the university’s Colorectal Research Center, and colleagues wrote.

“While some nutritional research has focused extensively on individual nutrients or foods in the relationships between diet and disease, a general diet can be more informative because humans typically consume a mixture of nutrients and foods,” they wrote. “Dietary indicators such as the DAI are one of the approaches to this effect.”

study was Posted online in Gastroenterology BMC.

Measuring antioxidant intake

Previous research has indicated an inverse relationship between DAI and inflammatory diseases, the study authors wrote, including stomach cancerAnd the colorectal cancernon-alcoholic fatty liver disease and obesity. Studies have indicated that H pylori The infection is associated with a deficiency of vitamins A, C, and E, which have antioxidant properties.

In the case-control study, the research team compared the dietary intake of 148 patients H pylori to 302 healthy controls without injury. patients in H pylori– The positive group was recruited between June 2021 until November 2021 from the gastroenterology clinic at Rasul Akram Hospital in Tehran, where they were newly diagnosed as having an active infection and not yet undergoing treatment.

The researchers calculated the DAI based on dietary intake information from the 168-item food frequency questionnaire used in Iran. Participants were asked about their dietary intake based on the average day, week, month and year. They also discussed food serving sizes and, to increase the accuracy of the estimates, interviewers showed home measurements or serving sizes to confirm the measurements with the participants.

The average age of study participants was 39 years, and about 60% were women. Compared with healthy controls, those with H pylori They were significantly older, had a higher body mass index, and smoked more.

In general, patients with H pylori Eating much less Vitamin AAnd the Vitamin EAnd the manganeseAnd the selenium. Other differences in dietary intake – for vitamin C and zinc – It wasn’t great.

The mean total DAI was significantly higher in healthy controls, at 7.67, compared to 3.57 in patients with H pylori. The risk of infection decreased with increased DAI continuous.

After adjusting for several variables, the researchers found that participants with lower than average DAI values ​​had an increased risk of developing H pylori infection.

“A balanced diet, especially a high consumption of fruits and vegetables, may protect people from the consequences of this H pylori infection,” the study authors wrote. Conversely, a diet full of carbohydrates and sweets is associated with H pylori the spread of infection.”

Why a good diet may help fight infection

The results are consistent with other studies that reported higher intakes of fruits and vegetables among healthy people compared to those who ate them H pylori Infections, the study authors write. Animal studies have also indicated that taking vitamins A, C, E and selenium can lead to a decrease in H pylori growth.

“Many biologically plausible reasons may explain why dietary antioxidants may, directly or indirectly, be a protective factor against H pylori The researchers wrote: “It is known that antioxidants, with their activity in scavenging free radicals, can inhibit the growth of H pylori. “

H pylori It is urease positive and can manufacture a large amount of urease for ammonia Produced to neutralize stomach acid, allowing it to colonize in the gastric epithelium, the study authors wrote. Vitamin C inhibits urease activity and improves stimulation grains, macrophages, lymphocytes, and immunoglobulin production. Other nutrients, such as zinc, may inhibit the enzyme urease H pylori They write about sticking to stomach tissue.

Richard Beck Jr., MD

“It has been previously shown that nutrients dramatically alter pathogenic responses H pylori Richard Beck Jr., MD, professor of medicine and director of gastroenterology at Vanderbilt University Medical Center, said, Medscape Medical News.

Peek, who was not involved in this study, and colleagues discovered that iron deficiency is associated with altered bile metabolism, which can enhance H pyloriCarcinogenesis caused by the stomach.

“The current study is important, as it suggests that switching to a diet rich in antioxidants may be beneficial in terms of H pylori infection.”

At the same time, Peek has expressed caution about generalizing the findings across population groups.

“It is likely that most of the people enrolled in this study were infected H pylori as children.” Therefore, the reverse role of diets rich in antioxidants and H pylori Care must be taken when interpreting the infection.”

Future studies should confirm results in other groups and determine whether diets rich in antioxidants reduce the diseases they cause H pylori Infection, added a peek.

The study was not funded by any research center, and the authors did not declare any conflict of interest. Peek reported no relevant disclosures.

BMC Gastroenterol. Posted online September 6, 2022. full text

Caroline Krist is a health and medical journalist reporting on the latest studies for Medscape, MDedge, and WebMD.

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