Common uses, medications, and side effects

Simply put, an antiprogestin is a substance that prevents the body from producing or using a hormone called progesterone.

Progesterone is one of the main female sex hormones. Prepares the body for pregnancy and stay in it, and regulates the menstrual cycle.

By stopping the action of progesterone, antiprogestins can affect the lining of the uterus and cause uterine contractions, which It can lead to end of pregnancy.

Antiprogestins work in many different ways. They mainly block the action of progesterone.

When antiprogestins bind to the body’s progestin receptors and stop the production or use of progesterone, the lining of the uterus breaks down, leading to menstruation.

Increased antiprogestin The concentration of prostaglandins, which helps to stimulate the contraction of the uterine muscle wall, which leads to menstrual bleeding. Antiprogestins also stop cortisol from binding to certain receptors, which boosts circulating cortisol levels and relieves high blood sugar levels.

Research has shown Antiprogestins may kill and stop the growth of cancer cells in breastsAnd the ovariesand the cervix as well.

If antiprogestins block progesterone, what do progestins do?

Well, these are just synthetic substances that bind to receptors in the body and produce results similar to natural progesterone.

You are You may have heard of Progestin in relation to things like hormonal contraceptives and hormone replacement therapy.

Basically, antiprogestins and progestins play opposite roles. One stops the hormone progesterone, and the other is a synthetic version of the hormone.

People First time use Antiprogestins for emergency contraception and termination of pregnancy.

people today still used in these areas –Especially for the termination of pregnancy up to 10 weeks.

But people also use it to treat other gynecological conditions, such as endometriosis and high blood sugar levels in people with Cushing’s disease.

The ability of antiprogestins to block progesterone can be useful in treating some symptoms of menopause, such as hot flashes.

People can use antiprogestins alone, in some cases, or with other treatments.

The experts are I’m still studying Breast cancer treatment with antiprogestins.

Or not Developed in 1980Mifepristone is the most well-known antiprogestin. You may also see that people refer to it as RU 846 or Mifeprex.

People usually use it with another medicine called misoprostol to terminate early pregnancy.

Medical abortion, as it is known, involves taking mifepristone first. This binds to progesterone receptors within the body, preventing the production and use of progesterone, which is what your body needs to help the pregnancy develop.

It can also cause the uterus to contract.

The misoprostol then lubricates the cervix, which eventually causes the body to expel the pregnancy from the uterus.

Korlym is another name for mifepristone used to treat symptoms of Cushing’s disease.

Emergency contraceptives that act as antiprogestins contain ulipristal acetate.

Antiprogestin drugs are not suitable for everyone, including these With an ectopic pregnancy or intrauterine device or severe anemia.

If you have a bleeding disorder or are allergic to compounds like prostaglandins, you may also have difficulty taking antiprogestins.

Common side effects of taking antiprogestins to terminate pregnancy included:

  • cramps
  • vaginal bleeding
  • nausea
  • vomiting
  • Fever
  • goosebumps
  • Diarrhea
  • Headache

And if your doctor prescribes an antiprogestin for other reasons, you can too expertise:

  • nausea
  • vomiting
  • Stomach or pelvic pain
  • fatigue
  • Headache
  • Diarrhea
  • Menstrual disorders

Rare side effects of mifepristone ranging from skin reactions to uterine rupture and toxic shock syndrome.

If you feel unwell after taking an anti-progestin medication, it is a good idea to speak with a doctor as soon as possible.

They can advise you on relieving side effects and can see you in person for an examination if necessary.

Get immediate medical attention if you experience Serious side effectsSuch as:

  • swelling
  • breathing difficulties
  • Sharp pain
  • weakness
  • Very heavy bleeding, soaking one or more menstrual pads per hour

Antiprogestins mainly block the hormone progesterone, which makes them useful for early-stage abortion and emergency contraception.

But they can also relieve symptoms of conditions such as endometriosis and Cushing’s disease, and they may also help treat some types of cancer.

Side effects such as headache, diarrhea, cramps, and nausea can occur. But if you’re concerned about any symptoms you’re experiencing, contact a healthcare professional for some personal advice.


Lauren Sharkey is a UK-based journalist and writer who specializes in women’s issues. When you’re not trying to figure out a way to banish a migraine, it can be found revealing answers to your underlying health questions. She has also authored a book on young women activists around the world and is currently building a community of these resistance fighters. catch her Twitter.