“The new study hypothesizes that due to the superior antioxidant and anti-inflammatory properties of tocotrienols, this vitamin E isomer may be more effective than alpha-tocopherol for those with fatty liver disease,”Researchers wrote.
According to the Mayo Clinic, NAFLD affects approximately 80 to 100 million adults in the United States and can progress to the more serious non-alcoholic steatohepatitis (NASH).
Delta Tocotrienol vs Alpha Tocopherol
Delta-tocotrienol – A powerful antioxidant containing vitamin E found in annatto, a red lipstick extract derived from the seeds of the achiote tree (pixa oriana)It was first isolated by biochemist and vitamin E expert Barry Tan.
It has been sold as DeltaGold by the natural health research and development company American River Nutrition since 1998, and marketed as “Vitamin E is fifty times stronger and faster”In support of immune health and antioxidants.
“Recent research shows that annatto contains tocotrienols, a phytonutrient with extraordinary antioxidant properties.” The company announces
“Annatto is the only plant source that exclusively provides delta and gamma tocotrienols – the most potent forms of Vitamin E. Annatto is also free of tocopherols, which is an important advantage because alpha-tocopherol interferes with the biochemistry of tocotrienols. “
On the other hand, alpha-tocopherol is the most prevalent of the eight forms of vitamin E. It is currently recommended at a dose of 800 IU daily as a complementary treatment for NASH along with enhanced diet and exercise.
American River Nutrition deals with that Unfortunately, vitamin E in the form of alpha-tocopherol has not received good review by the United States Preventive Services Task Force.In the June 2022 Journal of the American Medical Association for the primary prevention of cardiovascular disease or cancer.
The active-control double-blind trial randomly assigned 100 patients with nonalcoholic fatty liver to receive 300 mg of delta-tocotrienol or 268 mg of alpha-tocopherol twice daily for 48 weeks. Clinical evaluation, biochemical analysis and CT scan of the liver were performed at baseline, 24 weeks and 48 weeks.
The study found that two phytonutrients had equally beneficial effects in improving hepatic steatosis, oxidative stress and insulin resistance, but delta-tocotrienols were more effective than alpha-tocopherol in reducing WT inflammation and apoptosis associated with NAFLD.
“This is the first time that delta-tocotrienol has been compared head-on with alpha-tocopherol, and the results did not disappoint,” Tan said, noting that previous trials comparing DeltaGold to a placebo group in NAFLD patients have produced similar positive results.
“With the significant advantages of tocotrienols over tocopherols for weight loss and inflammation, it is time to update the vitamin E guidelines for patients with nonalcoholic fatty liver disease.”
Annatto tocotrienols are also clinically proven to support cardiovascular health, boost bone health, reduce inflammation, maintain blood sugar levels, boost brain health, lower fat and increase the life expectancy of cancer patients.
Source: Complementary therapies in medicine
dui: 10.1016 / j.ctim.2022.102866
Comparison of the effects of delta-tocotrienol and alpha-tocopherol on hepatic steatosis and inflammatory biomarkers in patients with nonalcoholic fatty liver disease: a randomized, double-blind controlled trial.
Authors: Pervez MA et al.