It was found that a topical ointment made from tree sap is effective in treating infections of skin wounds

Science Translational Medicine (2022). DOI: 10.1126 / scitranslmed.abn3758″ width=”800″ height=”530″/>

EBC-1013-induced healing in a calf wound model with acute thermal burns. Pictures (A) Hair clipping, local anesthesia with neuroanaesthesia. (B and C) Calf venting with a displacement iron (at 500℃) resulting in two-thickness burn wounds. (D) Photograph of the extraction site immediately after the extracted iron was removed showing the localized area of ​​the burn. (e) Wound images of Day 0 +/- EBC-1013 treatment (3 mg/ml) in a calf wound model. (F) Percentage of wounds that healed at day 28 within the calf wound model (n = 12). (g) Histological scores from wound biopsies at day 0, 7 and 14 indicative of ulceration, granulation tissue, new collagen, neutrophils, chronic inflammatory cells and bacteria. Data are shown as mean ± SEM. attributed to him: Translational Medicine Sciences (2022). DOI: 10.1126 / scitranslmed.abn3758

A team of researchers affiliated with multiple institutions in the UK and Australia has developed an unconventional ointment for treating skin wound infections based on a molecule found in the sap of the Queensland blush tree. The study was published in the journal Translational Medicine Sciences.

Previous research (and anecdotal evidence) has shown that the Queensland blush tree has medicinal properties – its sap is currently being studied by another team to find out if it may help in treatment. cancer patients. In this new effort, researchers studied the sap and used it to make an ointment as a treatment for hard-to-treat open skin wounds.

Open skin wounds have become a major problem in recent years due to the large number of people with diabetes. People with this disease decreased blood flow to their feet, leaving them vulnerable to chronic, non-healing skin wounds. These wounds are particularly prone to bacterial infections that are difficult to treat because the bacteria create membranes that prevent antibiotics. Medical scientists also prefer not to treat such infections with conventional antibiotics because they speed up the rate of immunity against such treatments.

In this new effort, researchers examined sap samples from the blush tree and identified a molecule that appears to be a promising candidate for treatment. open wound bacterial infections; The molecule is called EBC-103, and it interferes with the structure of biofilms, allowing immune system to launch an attack. They also found that the molecule caused inflammation in the area where it was applied, which also aided in healing.

The researchers made an ointment using the molecule and applied it to calves with wounds from removing horns. They found that the ointment not only prevented bacterial infectionIt also speeds recovery – 75% of calves were fully recovered after 28 days, compared to only 25% of those who were not treated.

Hydrogen peroxide antibiotic-free electronic bandages treat wound infections

more information:
Lydia C. Powell et al, Topical immunomodulating Tiglian epoxy disrupts biofilms and healing in acute and chronic cutaneous wounds, Translational Medicine Sciences (2022). DOI: 10.1126 / scitranslmed.abn3758

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