Researchers at the University of East Anglia in the UK say they have made an important discovery about how prostate cancer starts to develop.
A new study was published in Molecular Oncology It reveals that the prostate as a whole, including the cells that appear normal, is different in men with prostate cancer. It is suggested that tissue cells throughout the prostate are predisposed and predisposed to developing prostate cancer.
This means that it may be best to treat the entire prostate rather than only the areas of the prostate affected by cancer.
The team hopes the work will help scientists better understand the reasons for this Prostate cancerAnd even ban it completely.
Lead researcher Daniel Brewer, from Norwich Medical School at the University of East Anglia, said: ‘Prostate cancer is the most common type of cancer in men and kills one man every 45 minutes in the UK. Clusters of cancer cells in more than one place inside the prostate.
“We wanted to find out if this was due to changes in ‘normal’ prostate cells throughout the prostate.”
cancer Driven by changes in DNA. The team studied the DNA code in 121 tissue samples taken from 37 men with and without prostate cancer.
“The samples we studied included tissue that comes from cancer and tissue from elsewhere in the prostate, which looks normal under a microscope,” Brewer said.
“This results in a huge amount of data and by applying a great deal of computer power we can pinpoint the differences that occurred in the DNA, which gives us insight into how the cancer grows. We found that ‘normal’ prostate cells in men with prostate cancer had mutations (changes). in DNA) more ‘normal’ prostate cells than men without prostate cancer.”
Breuer added that based on the genes of the samples analyzed, maps were created to understand where the various mutations occur. Researchers have shown that in most men, mutations in normal cells are different from mutations in cancer cells.
“Normal” prostate cells in men with prostate cancer appear to provide a beneficial environment for prostate cancer cells to develop and grow. In other words, the entire prostate is predisposed and predisposed to developing prostate cancer driven by a biological process as yet unknown.
This work has improved our knowledge of how prostate cancer first developed and may one day give us clues about how to prevent or treat it. It shows that it may be best to treat the entire prostate and not just the areas of the prostate affected by cancer.”
Hayley Luxton, senior director of Impact Research in Prostate Cancer UK, said: “This exciting new research shows for the first time how normal cells in the prostate can facilitate the growth and spread of prostate cancer.
Researchers have found that normal prostate cells in men with prostate cancer have certain genetic changes that make them act as a rich fertilizer, providing an ideal environment for the growth and development of prostate cancer cells. These findings give us important new insights into the early development of prostate cancer, which may one day give us clues about how to prevent it.”
This research was led by UEA, in collaboration with the University of Cambridge, Cancer Research London, the Wellcome Sanger Institute, the universities of Oxford, St Andrews, York, Manchester, Tampere (Finland) and University College London – as well as the University Hospitals Cambridge NHS Foundation Trust and the University of Cambridge Foundation Trust. Royal Marsden NHS Foundation, HCA Healthcare UK Laboratories and Earlham Institute.
It was funded by Cancer Research UK, the Dallaglio Foundation, and the UK’s Movember Award for Training, Leadership and Development for Prostate Cancer.
The project has also received support from Prostate Cancer Research, the Big C Cancer Charity, the Bob Champion Cancer Trust, The Masonic Charitable Foundation that succeeded The Grand Charity, the Alan Boswell Group, The King Family, and the Hargrave Foundation.