Podcast: Friday Five Weekly News Report in Health Research

cell song It begins with the discovery of cells and germ theory, and features such figures as Louis Pasteur and Robert Koch, who brought the cell “in close contact with pathology and medicine.” This intercourse will transform biomedicine, leading to the insight that we can treat disease by thinking at the cellular level. The slightest rearrangement of diseased cells may be the path toward relieving an organism’s suffering: eroding the cell walls of bacteria while preserving our human cells; The invention of a mediator convinces the sperm and the egg to dance in the cell union for in the laboratory fertilization (IVF); designing molecular rockets that harbor receptors that decorate the outer surface of cancer cells; Teaching adult skin cells to remember their embryonic state for renewable drugs.

Mukherjee uses the bulk of the book to illustrate the major cell types in the human body, along with the “connective relationships” that enable major organs and organ systems to function. This includes the immune system, heart, brain, etc. Mukherjee’s distinctive style is characterized by compelling anecdotes and human stories that revive the scientific (and non-scientific) processes that have led to our current state of understanding. In his chapter on Neurons and the Brain, for example, he incorporated Santiago Ramón y Cajal’s fine black ink drawings of neurons in Mukherjee’s personal encounter with clinical depression. In one clear section, he interviews Dr. Helen Mayberg, a leading neurologist who takes seriously the descriptive power of her patients’ metaphors, because they suffer from the “caves,” “holes,” “voids,” and “force fields” that make their lives gray. Dr. Mayberg aims to stimulate patients’ neurons in a way that restores colour.

Besides revealing the insight and innovation that has arisen from cell-based thinking, Mukherjee’s larger project appears to be a cognitive one. The first chapters of The cell song Constantly hinting at the possibility of redefining the basic unit of biology as the cell rather than the gene. Choosing a biomedical center around cells is, above all, a clear choice Not To center around genes (the subject of Mukherjee’s previous book, gene), because genes dominate popular scientific communication.

This selection of cells over genes is most welcome. cells are alive. Genes are not. The letters – such as As, Cs, Gs, and Ts representing the DNA nucleotides that make up our genes – must be grouped into a word, poem or song that offers a glimpse into deeper truths. The main idea embedded in this thinking is an idea Appearance of. Whether in ancient myth or modern art, creation tends to be an emergent process, not a linear cipher. The cell is currently our best guess of the basic unit of life evolution, converting a limited set of chemical building blocks — nucleic acids, proteins, sugars, and lipids — into a proliferating and evolving system to combat stasis and entropy. The song of the cell is the song of our time, as it lauds the genesis of biology from chemistry and physics, to the “frantically energetic process” of equilibrium.

Refocusing our view of biology has practical consequences, too, for the way we think about diagnosing and treating diseases, and for the invention of new drugs. Centering the cells is a challenge: What type of cell should be placed in the center? Rather than default to the apparent simplicity of DNA as a symbol because it is the only major symbol of life, the stress of defining cell diversity—a mapping process that is still far from complete in cutting-edge biology laboratories—could help create a more thoughtful library of cellular metaphors to shape each From practicing biology and communicating with him.

Moreover, effective problem solving is often all about working at the right level or at the right scale. cell Feel Like the appropriate level for interrogating the many ailments that trouble us, because the senses that guide our own perceptions of illness and health—the burning pain of inflammation, the tunnel vision of a migraine, the vertigo caused by a shivering heart—emerge.

This, unfortunately, is kind of where Mukherjee leaves the reader, as he explores the consequences of the biology of appearance. Many practical and profound questions relate to the ways in which each level of life feeds on the others. In a book on cells and ‘future human’ I wish Mukherjee had created more space to research the ways cells would form and be shaped by the future of humanity and so on.

For example, when discussing the regenerative power of pluripotent stem cells, Mukherjee evokes the philosophical thought experiment of the Delphic boat, also known as the Ship of Theseus. The boat is made of many wooden pieces, each of which has been replaced for repair over the years, and the structure of the boat has not changed. In the end none of the original wood of the boat was left: is it the same boat?

Mukherjee raises Delphic’s boat in one paragraph at the end of the chapter about stem cells, as a metaphor regarding the possibility of stem cells regenerating forever. It doesn’t follow any of the threads of possible answers. Given the current state of cellular engineering, of which Mukherjee is a world expert on through his work as a physician and scientist, this book could have used an entire section devoted to examining this question and, more importantly, the ways in which this thought experiment breaks down.

We are entering a phase of real-world bioengineering that is characterized by the formation of cellular parts within cells, cells within organs, organs within the body, and bodies within ecosystems. In this reality, it would be unwise to assume that any whole is just the sum of its parts. The perfection of any of these measures of life – organelle, cell, organ, body, ecosystem – is what is at stake if we allow biological reduction to assume the relationship between those measures.

In other words, Mukherjee succeeds in providing a witty and compelling account of the lives of the many cells that appear to resurrect us. Like his previous books, it is useful to read for anyone curious about the role of cells in disease and in health. However, it fails to provide the broadest Context From The cell song.

As pioneering agronomist and essayist Wes Jackson writes, “The in-house amino acid sequence in the human cell, when produced within the bacterial cell, does not fold quite properly. Something in the internal environment of E. coli affects the tertiary structure of the protein and renders it inconspicuous. Active. The whole in this case, the Escherichia coli cell, affects the segment – the newly made protein. Where is the priority of the segment now?” [1]

Besides the ways in which the different kingdoms of life translate the same genetic code, the practical situation of humanity today relates to the ways in which different disciplines of modern life use values ​​and culture to influence our genes, our cells, our bodies, and our environment. Humans may soon become a a little Like a Delphic boat, it’s filled with two tons of fresh cells to refill different ports within our bodies, for a longer, healthier life. But in biology, as in writing, a mixed metaphor can cause a bit of a cacophony. We are not boats with parts to be replaced in piecemeal. Nor whales, nor alpine forests, nor topsoil. Life is not the sum of the parts, and neither is a song that really makes a sound.

[1] Wes Jackson, “Insights and Assumptions” in Nature as a measure (pp. 52-53).