Premature aging may play a role in the development of chronic kidney disease

September 22 2022

1 minute reading

source:

Stenvinkel P. 2022 Chronic kidney disease – a clinical model for premature aging. Presented at: International Conference on Hemodialysis. 21-22 September 2022; (virtual meeting).

Disclosures:
Stenfinkel reports that he is a member of the scientific/medical advisory board for Astra Zeneca.


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A better understanding of chronic kidney disease can be found in the study of aging, according to a presenter at the International Conference on Dialysis.

As did Helio Previously mentionedAging increases the spread of some diseases, including chronic kidney disease. Moreover, the loss of kidney function may break the connection between chronological age and biological age, according to Presentation.

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run out stone cornerMasters, PhD, Professor of Renal Medicine at Karolinska University Hospital of Karolinska Institutet in Sweden and colleagues conducted experiments using DNA methylation clocks to measure biological aging in patients with chronic kidney disease. Analyzes revealed that patients had an older biological age before dialysis or at the time of transplantation; Therefore, the researchers said, patients with chronic kidney disease may undergo premature aging.

Additionally, Nrf2 depletion, mitochondrial dysfunction, oxidative stress and loss of gut biodiversity contribute to aging, Stenfinkel said. There are also well-established environmental risks that can increase aging, he added. For example, climate change, water shortages, and heat waves can have a significant impact on the aging process of a patient with chronic kidney disease.

In the presentation, Stenvinkel noted that the life span of animals is different from that of humans, but that there is something to be learned in the way animals live.

“I was interested in hibernating bears, because they are metabolic witches,” Steenfinkel said. “Anyone who can survive well without urinating for 6 months should interest nephrologists.”

Even in high-risk conditions for chronic kidney disease, he said, bears show high levels of phosphatidylcholine. Stenfinkel suggested that the key to slowing aging may be found in diet and gut microbes, and noted that tigers and lions eat red meat and are highly susceptible to chronic kidney disease.

However, there is another aspect of the diet to consider in humans, and that is the industrial microbiome.

“The food processing They may be harmful,” Steenfinkel said. There is a direct relationship between phosphate and death. […] We are exposed to processed foods and medicines, climate change, water shortages and a sedentary lifestyle, which will increase the risks and trigger this disease of aging,” Steenfinkel said. “We urgently need to find solutions on how to break this vicious cycle.”