Research pits beta radiation mimicry in cancer treatment versus the analytical method

A new paper has been published in EHR Plus Authored by Eduardo de Paiva, Department of Medical Physics at the Institute of Radiation Protection and Dosimetry, Rio de Janeiro, Brazil, the gold standard simulation method used to calculate the interaction of ionizing radiation with matter and estimate the radiation dose is etched into a target organ – a Monte Carlo (MC) simulation – versus an alternative analytical method, the Loevenger formula.

New research between simulated beta radiation doses in oncology versus an analytical method.

Treating superficial skin tumors, especially when they are above cartilage or bone with beta radiation, can help protect sensitive structures while treatment is being offered.

However, the use of short-range beta radiation in the treatment of cancer is not without its drawbacks, especially when it comes to the measurement of radiation exposure – dosimetry. When experimental dosimetry is not feasible, researchers use simulations and calculations to study the interaction of ionizing radiation with the substance and to estimate the dose of radiation delivered to the target organ.

A new paper has been published in EHR Plus Authored by Eduardo de Paiva, of the Department of Medical Physics at the Institute of Radiation Protection and Dosimetry, Rio de Janeiro, Brazil, and colleagues, they set the gold standard for simulation techniques—Monte Carlo simulations (MC)—as opposed to an alternative analytical method, the Loevinger formula.

We measured the dose of the treatment instrument using mathematical techniques – simple technique, no experience needed and no practical challenges. The comparison between the MC simulation and the Loevinger formula in our research setting was the novelty of our study.”

Eduardo de Paiva, Department of Medical Physics, Institute of Radiation Protection and Dosimetry, Rio de Janeiro, Brazil

Non-experimental dosimetry techniques such as MC simulations are useful for their ability to handle different geometries and materials, but MC simulations require heavy computation and this can hamper their implementation.

Analytical methods are another group of beta radiation dosimetry techniques that can produce faster results than MC methods. Until now, these methods have been less preferred because they are associated with lower accuracy.

The team used MC simulation and analytical computation – the Loevinger formula – to dose the radiation dose from the Multiwell skin brachytherapy instrument with two beta sources. The results of the two approaches were compared to determine the accuracy of the analytical method.

“Loevinger’s formula, a rapid method of dosimetry, showed good agreement with the gold-standard Monte Carlo methods,” concluded Paeva. “Thus, the Loevinger formula can be used, as a basis for a dosimetry program, for direct dosimetry of beta sources in simple geometries.”

source:

Journal reference:

De Paiva, E.; et al. (2022) Calculations of beta radiation doses from an application of multiwell phosphorous-32 and yttrium-90 designed for use in the treatment of superficial skin tumours: comparison of Monte Carlo and analytical methods. EHR Plus. doi.org/10.1140/epjp/s13360-022-03116-5.