What are the possible side effects of Omicron’s COVID-19 booster shots? – NBC Chicago

With the arrival of the long-awaited COVID-19 booster shots intended to target the BA.4 and BA.5 sub variants of Omicron, many may be curious about its potential side effects.

Well, the new boosters may actually not differ from previous renditions of vaccines in terms of side effects.

“We don’t have any data on this [yet]basically giving two vaccines in one shot — but biologically, I wouldn’t expect the side effects or the severity of the vaccines or their safety characteristics to be any different than current mRNA vaccines and boosters,” said Dr. Paul Offit, director of the Vaccine Education Center at Children’s Hospital of Philadelphia and member of FDA independent advisory group, for CNBC Make It.

The reformulated shots from Pfizer and Moderna are bivalent, meaning they target both the original COVID strain and omicron’s BA.5 and BA.4 variants.

Appointments to receive the updated shots at Chicago-area pharmacies have been ramped up, as Illinois health officials have urged community members to get the new dose.

“These new bivalent vaccines are designed to provide additional protection against the Omicron variants, which are now the dominant strain of the virus,” Illinois State Director of Public Health, Dr. Samir Vohra, said in a statement. Important for those at risk of serious outcomes, updated vaccines provide protection from hospitalization and even death.”

The vaccine is now the primary vaccine that will be given to those who qualify and are looking to boost across the country.

“With this new mandate, monovalent doses – the old version – are no longer allowed as boosters,” Dr. Alison Arwady, Chicago Public Health Commissioner, said earlier. “We really want people to get these updates. So, anyone over 12 who’s looking for a booster, that’s the one who’s going to get them. People from ages 5 to 11 can still get the original boosts.”

Expected side effects

Side effect data is not yet available because new enhancers have been previously approved Food and Drug Administration And the Centers for Disease Control and Prevention before completing their clinical trials fully.

in Pfizer And the the talk In clinical trials of BA.1 shots, participants who were already fully vaccinated with a booster dose received an updated booster dose. In both clinical trials, the most common side effects reported within seven days of receiving the injection were:

  • Pain
  • fatigue
  • Headache
  • muscle pain
  • goosebumps
  • Joint pain
  • Redness and swelling at the injection site
  • Fever

This is a familiar list: It’s the same set of side effects that came with the original formulations. But in particular, in those clinical trials, the severity of the side effects was very mild.

The Pfizer trial found that about 52% of participants who received the BA.1 dose experienced mild pain at the injection site, 8% experienced moderate pain and only 0.3% experienced severe pain. Nearly 26% of the participants experienced a mild or moderate headache, while only 0.3% experienced a severe headache.

The Moderna trial found that approximately 59% of participants experienced fatigue, but only about 4% experienced it at the Grade 3 level, which is defined as significant fatigue that prevents daily activity.

Offit says that severe side effects are “generally more common” after receiving a second dose of the vaccine, rather than after receiving a third or fourth dose. You are only eligible for new boosters if you have completed the initial vaccination series, which means that most people have already received at least two doses early on.

same concept Achieved during the last round of reinforcement shots. Offit says the new shots have the same dose amounts as the original vaccines, which also suggests that their safety profiles could be similar.

A single dose of the monovalent Pfizer vaccine contains 30 micrograms of mRNA targeting the original Covid strain. Updated booster shots cGet the same number of microgramsWith 15 targeting the original strain, 15 targeting the original strain, and 15 targeting the BA.4 and BA.5 strain.

Moderna’s monovalent shot contains 50 micrograms of mRNA for each dose targeting the original strain. that it Updated booster Contains 25 mcg targeting the original strain, and 25 mcg targeting omicron sub-variants.

The BA.1 trials tested only a few hundred people, which is a relatively small sample size compared to the thousands of Americans who are due to receive the new BA.5 doses, Offit notes. He says you can still be confident going in, but not 100% sure what to expect.

“We have to keep our eyes wide open for side effects and adverse events that may occur, and still keep in mind that this is a new product,” Offit says.